Top 8 Vitamins & Multivitamin Supplements for Dogs in the USA (2025): A Vet-Informed Guide to Targeted Nutrition, Joint and Immune Support

VetriScience Canine Plus Senior Multivitamin ranks as the market leader for senior dogs by offering a veterinarian‑focused, higher‑potency formula that targets joint, cognitive and immune health alongside standard vitamins. Technically and financially it sits at the premium end compared with the other options, but its vet‑formulated reputation and senior‑specific dosing justify the higher cost for owners prioritizing clinically oriented daily care for older pets.

Zesty Paws 8-in-1 Multivitamin Bites for Puppies ranks as a best-in-class choice because its highly palatable soft-bite format and focused eight-target blend deliver puppy-specific nutrients (skin & coat, digestion, immunity and more) with broad retail availability and competitive price-per-dose. Compared with the other options on this list, Zesty Paws balances comprehensive benefits and affordability, making it a practical choice for owners who want a widely tested, easy-to-dose daily supplement during early growth.

Zesty Paws Senior Advanced Multivitamin earns best-in-class recognition for its broad, palatable soft-chew formula that combines joint, cognitive and digestive support tailored to older dogs; its modern ingredient blend (glucosamine, probiotics and antioxidants) makes it technically robust compared with simpler multivitamins. Financially, Zesty Paws balances premium features with frequent retail promotions and multi-pack options that often make it more affordable per dose than boutique alternatives like Pet Wellbeing.

Zesty Paws Omega Bites are flavored soft chews that combine omega fatty acids with added skin-support nutrients like biotin and vitamin E, making them a best-in-class option for owners who want palatable, multi-ingredient support for skin and coat. They stand out from straight oils and single-ingredient softgels by offering convenient daily dosing and broad formulation benefits, typically at a mid-range price per serving that balances variety and affordability.

Thorne Vet Canine Basic Nutrients is a veterinary-grade supplement formulated for clinicians and pet owners who need precise, research-backed nutrient levels and high purity, prioritizing measured immune and antioxidant support over palatability. Technically superior in raw ingredient testing and potency compared with consumer chewables, Thorne Vet is usually the most expensive option but offers the strongest quality assurance and dosing control for dogs with specific health needs.

K9 Power Go Dog positions itself as the best-in-class hydration and performance drink for active and working dogs, offering an electrolyte-forward formulation designed for rapid rehydration and endurance support. Compared with the gentler rehydration formulas on this list it emphasizes higher electrolyte concentration and sport-focused ingredients, making it technically suited for exercise and heat-stress scenarios while commanding a premium price-per-serving versus budget options.

PetAg Esbilac 2nd Step Puppy Weaning Food is included as the lead feeding product for lactation scenarios because it provides a nutritionally balanced transition food for pups when maternal milk is insufficient or supplementation is needed, complementing maternal prenatal supplements rather than replacing them. Its technical advantage over vitamin-only products is that it directly supplies calories and macronutrients for growing puppies; financially, it is more of a consumable feeding cost compared with one-time supplement purchases but is essential in mixed litters or orphaned-puppy care.